1988 Fitch Avenue
St Paul, MN 55108
- Postdoctorate, The University of Michigan Medical School & Walther Cancer Institute, 1991, Cell Signaling
- PhD. University of Minnesota, 1990, Animal Physiology/Neuroscience
- MS. University of Minnesota, 1983, Veterinary Physiology
Areas of Interest
- ANSC 3305: Reproductive Biology in Health and Disease
- ANSC 4009W: Undergraduate Senior Thesis: Science in Agriculture
- ANSC 4096: Professional Experience Program - Internship (mentor)
- ANSC 4305/5305: Companion and Wild Species Reproduction
- ANSC 8211: Animal Growth and Development
- ANSC / CMB 8344: Mechanisms of Hormone Action
Reproductive function in all animals encompasses the biochemistry, endocrinology and genetics of the unique tissues that enable procreation. An understanding of the physiological systems that regulate reproduction helps us treat the dysfunction of these tissues during disease and with exposure to environmental factors. I conduct research with scientific teams examining the role of ovarian steroids and endocrine disruptors in reproductive cancers and other disease states. Ongoing work with colleagues within the Physiology and Genetics division of the Animal Science department (Drs. Faulk, Saqui-Salces, Urriola) is focused on modulatory actions of methylation agents on the epigenetic landscape of reproductive tissues and the effects on reproductive function. In collaboration with the laboratory of Dr. Carol Lange in the University of Minnesota Masonic Cancer Center, we are examining the effects of progesterone receptor (PR) signaling in the early initiation and progression of high grade serous ovarian cancer (HGSC) within the fallopian tube.
Chaiworakul, V., S. Kosonsiriluk, L.J. Mauro, and M.E. El Halawani. 2017. Ovarian steroid withdrawal results in GABAA receptor upregulation in the photoperiodic neuroendocrine pathways of the turkey hen. Gen. Comp. Endocrinol. 240: 84-90.
Kosonsiriluk, S., V. Chaiworakul, L.J. Mauro, and M.E. El Halawani. 2016. Enhanced GABAergic inhibition in the premammillary nucleus of photorefractory turkey hens via GABA-A receptor upregulation. Gen. Comp. Endocrinol. 230: 57-66.
Diep, C.H., A.R. Daniel, L.J. Mauro, T.P. Knutson, and C.A. Lange. 2015. Progesterone actions in breast, uterine and ovarian cancers. J. Molec. Endocrinol. 54(2):R31-R53.
Kosonsiriluk, S., V. Chaiworakul, A. Thayananuphat, L.J. Mauro, and M.E. El Halawani. 2015. GABAergic neurotransmission in the premammillary nucleus of the turkey hypothalamus regulates reproductive seasonality and the onset of photorefractoriness. Neuroendocrinol. 103: 678-692. doi:10.1159/000442206.
Kosonsiriluk, S., L.J. Mauro, V. Chaiworakul, Y. Chaiseha, and M.E. El Halawani. 2013. Photoreceptive oscillators within neurons of the premamillary nucleus (PMM) and seasonal reproduction in temperate zone birds. Gen. Comp. Endocrinol. 190:149-155.
Kang, S.W., B. Leclerc, S. Kosonsiriluk, L.J. Mauro, A. Iwasawa, and M.E. El Halawani. 2010. Melanopsin expression in dopamine-melatonin neurons of the premammillary nucleus of the hypothalamus and seasonal reproduction in birds. Neurosci., Sep. 29;170(1):200-13.
Leclerc, B., S.W. Kang, L.J. Mauro, S. Kosonsiriluk, Y. Chaiseha, and M.E. El Halawani. 2010. Photoperiodic modulation of clock gene expression in the avian premammillary nucleus. J. Neuroendocrinol. 22(2):119-28.
Mauro, L.J., S.J. Wenzel, and G.M. Sindberg. 2010. Regulation of chick bone growth by leptin and catecholamines. Poultry Sci. 89:697-708. doi:10.3382/ps.2009-00363.
Kang, S.W., B. Leclerc, L.J. Mauro, and M.E. El Halawani. 2009. Serotonergic and catecholaminergic interactions with co-localised dopamine-melatonin neurons in the hypothalamus of the female turkey. J. Neuroendocrinol., Jan.;21(1):10-19.
Leclerc, B., S.W. Kang, L.J. Mauro, S. Kosonsiriluk, Y. Chaiseha, and M.E. El Halawani. 2009. Photoperiodic modulation of clock gene expression in the avian premammillary nucleus. J. Neuroendocrinol., Feb. 22(2):119-128. Epub Dec. 4, 2009. PMID: 20002961.
Schiller, K.R., M.R. Zilhardt, J. Alley, D.L. Borjesson, A.J. Beitz, and L.J. Mauro. 2009. Secretion of MCP-1 and other paracrine factors in a novel bone-tumor coculture model. BMC Cancer, Feb. 3;9:45.
Zeliadt, N.A., L.J. Mauro, and E.V. Wattenberg. 2008. Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3. Toxicol. Appl. Pharmacol., Nov. 1;232(3):408-17.
Schiller, K.R. and L.J. Mauro. 2005. Tyrosine phosphatases as regulators of skeletal development and metabolism. J. Cell Biochem. 2005 Oct. 1;96(2):262-77 (Review).
Warmka, J.K., L.J. Mauro, and E.V. Wattenberg. 2004. Mitogen activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic ras. J. Biol. Chem. 279(32):33085-33092.
Yunker, L.A., A. Undersander, J. Lian, G. Stein, C.S. Carlson, and L.J. Mauro. 2004. The tyrosine phosphatase, OST-PTP, is expressed in mesenchymal progenitor cells early during skeletogenesis in the mouse. J. Cell. Biochem. 93(4):761-773.
Zeliadt, N.A., J.K. Warmka, S.E. Winston, R. Kahler, J.J. Westendorf, L.J. Mauro, and E.V. Wattenberg. 2004. Tumor promoter-induced expression of the MMP-13 gene in a mouse keratinocyte model of initiated epidermis. Biochem. Biophys. Res. Comm. 317:570-577.
Mauro, L.J. and D. Foster. 2002. Regulators of telomerase activity. Am. J. Respir. Cell Mol. Biol. 26: 521-524.
Wheeler, M., M.K. Townsend, L.A. Yunker, and L.J. Mauro. 2002. Transcriptional activation of the tyrosine phosphatase, OST-PTP, during osteoblast differentation. J. Cell Biochem. 87:363-376 (featured cover article).
Morrison, D.F. and L.J. Mauro. 2000. Structural characterization and chromosomal localization of the mouse cDNA and gene encoding the bone tyrosine phosphatase, mOST-PTP. Gene 257(2):195-208.
Mauro, L.J., E.A. Olmsted, A. Davis, and J.E. Dixon. 1996. Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells. Endocrinol. 137 (3): 925-933.
Mauro, L.J. and J.E. Dixon. 1994. "Zip codes" direct intracellular protein tyrosine phosphatases to the correct cellular "address". Trends Biochem. Sci. 19:151-155.
Mauro, L.J., E. A. Olmsted, B.M. Skrobacz, A. Davis, R.J. Mourey, and J.E. Dixon. 1994. Identification of a hormonally regulated PTP associated with bone and testicular differentiation. J. Biol. Chem. 269 (48): 30659-30667.
Mauro, L.J., O.M. Youngren, J.A. Proudman, R.E. Phillips, and M.E. El Halawani. 1992. Effects of reproductive status, ovariectomy and photoperiod on vasoactive intestinal peptide in the female turkey hypothalamus. Gen. Comp. Endocrinol. 87: 481-493.
El Halawani, M.E., J.L. Silsby, and L.J. Mauro. 1990. Enhanced vasoactive intestinal peptide-induced prolactin release in the incubating turkey (Meleagris gallopavo). Gen. Comp. Endocrinol. 80: 138-145.
El Halawani, M.E., J.L. Silsby, and L.J. Mauro. 1990 Vasoactive intestinal peptide (VIP) as the hypothalamic prolactin releasing neuropeptide in the turkey (Meleagris gallopavo). Gen. Comp. Endocrinol. 78: 66-73.
Mauro, L.J., R.P. Elde, O.M. Youngren, R.E. Phillips, and M.E. El Halawani. 1989. Alterations in hypothalamic vasoactive intestinal peptide-like immunoreactivity are associated with reproduction and prolactin release in the female turkey. Endocrinol. 125: 1795-1804.
Book Chapters/Book Reviews
Mauro, L.J. 2013. More clinical concepts and less content: A different approach to pathophysiology. J. Microbiol. and Biol. Educ. 14(2): 282. Invited review of: Pathophysiology: A Clinical Approach; Braun & Anderson, 2011.
El Halawani, M.E., L.J. Mauro, R.E. Phillips, and O.M. Youngren. 1990. Neuroendocrine control of prolactin and incubation behavior in gallinaceous birds. In: Progress in Comparative Endocrinology, A. Epple, C.G. Scanes, and M.H. Stetson, Eds. Progress in Clinical and Biological Research, Vol. 342, Wiley-Liss Inc., New York, pp. 678-684.
El Halawani, M.E., O.M. Youngren, L.J. Mauro, and R.E. Phillips. 1990. Incubation and the control of prolactin secretion in the turkey. In: Endocrinology of Birds - Molecular to Behavioral, M. Wada, S. Ishii, and C. Scanes, Eds., Japanese Scientific Societies Press and Springer Verlag, Heidelberg FRG, pp. 287-295.
Mauro, L. 1987. Hematology and blood chemistry. In: Raptor Management Techniques Manual, B.A. Giron Pendleton, B.A. Millsap, K.W. Cline, and D.M. Bird, Eds., National Wildlife Federation, Washington, D.C. pp. 269-275.
Mauro, L.J., Seibel, M.I, Diep, C.H., Spartz, A., Perez Kerkvliet, C., Saini, S., Sesay, F., Litovchick, L., Drapkin, R., Schwartz, L.E., and Lange, C.A. 2019. Progesterone receptor (PR) signaling drives DREAM-mediated quiescence and cancer cell phenotypes in models of early HGSOC. 1st Annual Ovarian Cancer Midwest Focus Meeting, Minneapolis, MN. Nov. 4-5.
Mauro, L. 2017. “Sex steroid-BRCA interactions in hereditary ovarian cancer. Invited at 2017 Fall GynOnc Educ. Conf., Dept. of Obstetrics, Gynecology and Women’s Health, Univ. of MN. Nov. 28.
Mauro, L. and C. Lange. 2017. Hormones and heredity: Steroid receptor-BRCA interactions in ovarian cancer. Invited Presentation at monthly Gyn Onc Seminar Series, Mayo Clinic, Rochester, MN. Oct. 12.
Seibel, M.I., Spartz, A., Drapkin, R., Schwartz, L., Mauro, L.J. & Lange, C.A. 2019. Unique cell fates and metastatic phenotypes are activated by progesterone receptor (PR) isoform-specific gene expression in fallopian tube models of HGSOC. 2019 Endocrine Society meetings, New Orleans, LA. Chosen among top scoring abstracts for a Poster Discussion Session.
Seibel, M.I., Spartz, A., Drapkin, R., Schwartz, L., Mauro, L.J. & Lange, C.A. 2018. Progesterone receptor isoforms drive cell fate and metastatic phenotypes in human fallopian tube models of HGSOC. 8th Great Lakes Nuclear Receptor Conference, The Endocrine Society, Masonic Cancer Center, Mpls, MN. Awarded Best Research Abstract & Poster Presentation (free registration to 2019 Endocrine Society meeting and $1000 travel award to M. Seibel)
Seibel, M.I., A. Spartz, N. Temiz, L.J. Mauro, and C.A. Lange. 2017. Progesterone receptor (PR) isoforms drive distinct cell-cel interactions and gene expression programs in human fallopian tube models of early HGSOC. Proc., AACR Special Conf. on Ovarian Cancer, Pittsburgh, PA. Oct. 1-4. Abstr. B58.
Chaiworakul, V., S. Kosonsiriluk, M.E. El Halawani, and L.J. Mauro. 2016. Lessons learned from the turkey hen: Role of PMM and inhibitory GABAergic signaling in a wild temperate zone species. International Symp. on Avian Endocrinology, Niagara-On-the-Lake, Ontario, Canada. Oct. Abstr. #102.
Chaiworakul, V., S. Kosonsiriluk, L.J. Mauro, and M.E. El Halawani. 2016. The effect of ovarian steroid withdrawal on the photoperiodic reproductive neuroendocrine response in turkey hen via GABA-A receptor upregulation. International Symp. on Avian Endocrinology, Niagara-On-the-Lake, ON. Oct. Abstr. #90.
Kosonsiriluk, S., V. Chaiworakul, L.J. Mauro, and M.E. El Halawani. 2016. GABA circuitry of hypothalamic photoreceptive neurons regulates avian seasonal reproduction. International Symp. on Avian Endocrinology, Niagara-On-the-Lake, Ontario, Canada. Oct. Abstr. #103.
Diep, C.H., T.P. Knutson, L.J. Mauro, and C.A.Lange. 2015. FOXO1 is a key determinant of progesterone receptor isoform-specific senescence programming in ovarian cancer cells. In: Proc., AACR Specialty Conf. on Advances in Ovarian Cancer Res., Orlando, FL. Oct. 17-20. (Abstr. A39).
El Halawani, M.E. and L.J. Mauro. 2012. Modulation of fertility by GABAergic neurotransmission in the domestic turkey hen. USDA NIFA meeting. Poster presentation.
Kosonsiriluk, S., L.J. Mauro. V. Chaiworakul, Y. Chaiseha, and M.E. El Halawani. 10th International Symposium on Avian Endocrinology, June 5-9, 2012, Gifu, Japan. Invited presentation.
Kosonsiriluk, S., S.W. Kang, L.J. Mauro, J.R. Garbe, S.C. Fahrenkrug, and M.E. El Halawani. 2010. Gene expression profiling of dopamine-melatonin neurons in the avian premamillary nucleus. Poult. Sci. 89 (Supp 1): 564-565.
Leclerc, B., S.W. Kang, L.J. Mauro, S. Kosonsiriluk, and M.E. El Halawani. 2009. Photoperiodic modulation of clock gene expression in the avian premammillary nucleus dopamine-melatonin neurons. Poultry Sci. 88 (Suppl. 1): 127.
Sindberg, G.M., E. O’Brien, A.J. Beitz, and L.J. Mauro. 2009. Osteoblast-tumor interactions modulate TGFα-mediated regulation of MCP-1. In: Proc., 100th Annual Meeting of the American Assoc. for Cancer Res., Apr. 19-23, No. 339.
Kang, S.W., B. Leclerc, L.J. Mauro, and M.E. El Halawani. 2008. Serotonergic and catecholaminergic interactions with co-localized dopamine-melatonin neurons in the hypothalamic premamillary nucleus of the female turkey during different reproductive stages. Poultry Sci. 87 (Suppl. 1):15-16.
Leclerc B., S. Kang, C. Howell, L.J. Mauro, and M.E. El Halawani. 2008. Circadian expression of clock genes in the pineal gland, visual suparchiasmatic nucleus (vSCN) and premamillary nucleus (PMM) in photostimulated turkey hens. Poultry Sci. 87 (Suppl. 1): 14-15.
Okoye, N., M.R. Zillhardt, N.A. Zeliadt, E.V. Wattenberg, and L.J. Mauro. 2006. MAP kinase phosphatases-3 regulation in colorectal carcinoma. J. Minn. Acad. Sci. 69: 19 (Abstract - Winchell Undergraduate Research Symposium - Spring 2006).
Schiller, K.R., M.R. Zillhardt, A.J. Beitz, and L.J. Mauro. 2006. Regulation of CCL2 in a novel fibrosarcoma-bone co-culture model. In: Proc. of 97th Annual Meeting of AACR, Apr. 2006; 63-64.
Zillhardt, M.R., A. Undersander, C.S. Carlson, and L.J. Mauro. 2006. Leptin and its neural effectors can modulate long bone growth in the chick. Poultry Sci. 85 (Suppl. 1):120.
Petryk, A., W. Shawlot, M.P. Jarcho, L. Yunker, I. Leaf, L.J. Mauro, C.S. Carlson, and M.B. O’Connor. 2002. The role of twisted gastrulation in the development of axial skeleton in mice. Cell and Dev. Biol. Symp., Minneapolis, MN.
Yunker, L.A., C.S. Carlson, and L.J. Mauro. 2002. Spatial and temporal expression of the tyrosine phosphatase, OST-PTP, during osteogenesis. Amer. Soc. of Bone and Mineral Res. Meeting, San Antonio, TX.
Mauro, L.J., M. Wheeler, D.C. Tranter, M.K. Townsend, and E. Kishel. 2001. Cell-cell/ cell-matrix interactions and hormonal bone modulators regulate the mOST-PTP gene in MC3T3 osteoblasts. Amer. Soc. of Bone and Mineral Res. Meeting, Phoenix, AZ.
Honors and Awards
- 1993-1995 Research Investigator, University of Michigan Medical Center, Dept. of Biological Chemistry & Walther Cancer Institute
- 1995-2000 Research Assistant Professor, University of Minnesota, Dept. of Biochemistry
- 1996-prsnt Associate member, Masonic Cancer Center
- 2000-2006 Assistant Professor, Univ. of Minnesota, Dept. of Animal Science-Physiology
- 2006-prsnt Associate Professor, Univ. of Minnesota, Dept. of Animal Science
- 1997-1998 NIH James A Shannon Director’s Award
- 2011-2013 ASM/NSF Biology Scholar
- 2013 National Society of Collegiate Scholars – Distinguished faculty
- 1998 U.S. Patent No. 5,821,084 ;"Osteoblast-testicular protein tyrosine phosphatase" Assignees: Wyeth-Ayerst Research & The Regents of the University of Michigan [Co-inventor w/ J. E. Dixon]
- 2018-20 Minnesota Ovarian Cancer Alliance (MOCA) – Targeting DNA-PK damage - sensing kinases in hereditary ovarian cancer (Co-PI; with Carol A. Lange)
- 2015 Minnesota Ovarian Cancer Alliance (MOCA) – BRCA deficiency drives an enriched sex steroid milieu that promotes hereditary ovarian carcinogenesis (Co-PI)
- 2015 Grant-In-Aid (UMN OVPR) – Sex hormone dysfunction in hereditary breast & ovarian cancer (PI)
- 2012-15 USDA/NRI – Modulation of fertility by GABAergic neurotransmission (Co-I)
- 2008-10 MN Obesity Ctr/NIH-NIDDK – Role of Skeletal Hormones in Adipocyte Function (PI)
- 2007-12 NIH/NCI – Cancer Pain: Nerve/Tumor Interactions (Co-I)
- 2005-10 NIH/NCI – Negative Regulators: Key Determinants in Carcinogenesis (Co-I)
- 1998-03 NIH/NIAMS - Function of tyrosine phosphatase, OST-PTP, in osteogenesis (PI)