Scott M OGrady

Hudock, K.M., M.S. Collins, M.A. Imbrogno, E. Kramer, J. Brewington, A. Ziady, N. Zhang, J. Snowball, Y. Xu, B. Carey, Y. Horio, S.M. O’Grady, E. Kopras, J. Meeker, H. Morgan, A. Ostmann, E. Skala, M. Seifert, C.L. Na, K. Gollomp, N. Mangalmurti, B. Trapnell, J. Clancy, Alpha-1 Antitrypsin Limits Neutrophil Extracellular Trap Disruption of Airway Epithelial Barrier Function, Front. Immunol., (Molecular Innate Immunity), 13: 1-18, January 10 2023. https://doi.org/10.3389/fimmu.2022.1023553 (IF = 8.8).

Srisomboon, Y., K. Iijima, M. Colwell, P.J. Maniak, Marissa Macchietto, C. Faulk, H. Kita, S.M. O’Grady, Allergen-induced DNA release by the airway epithelium amplifies type 2 immunity, J. Allergy Clinical. Immunology 151(2): 494-508, February 2023. https://doi.org/10.1016/j.jaci.2022.09.034 (IF = 14.3). https://www.aaaai.org/tools-for-the-public/latest-research-summaries/the-journal-of-allergy-and-clinical-immunology/2022/dna

O’Grady, S.M., H. Kita, ATP functions as a primary alarmin in allergen-induced type 2 immunity, Am. J. Physiol. Cell Physiol., 325(5): C1369-1386, November 2023. https://doi.org/10.1152/ajpcell.00370.2023 (IF = 5.5)

Srisomboon, Y., K. Iijima, M. Colwell, P.J. Maniak, Marissa Macchietto, C. Faulk, H. Kita, S.M. O’Grady, Allergen-induced DNA release by the airway epithelium amplifies type 2 immunity, J. Allergy Clin. Immunol. https://doi.org/10.1016/j.jaci.2022.09.034 (Oct 25, 2022) (IF = 14.29)

Srisomboon, Y., Ohkura, N., Iijima, K., Kobayashi, T., Maniak, P.J., Kita, H., O’Grady, S.M., Airway exposure to polyethyleneimine nanoparticles induces type 2 immunity by a mechanism involving oxidative stress and ATP release. International Journal of Molecular Sciences, 22 (16), 9071-9089, 2021.

Srisomboon Y, Squillace DL, Maniak PJ, Kita H, O'Grady SM. Fungal allergen-induced IL-33 secretion involves cholesterol-dependent, VDAC-1-mediated ATP release from the airway epithelium. J Physiol., 598 (10):1829-1845. 2020.

Editors’ Choice Award: The Journal of Physiology. This paper was highlighted in the Perspectives article by: Ahmad S and A. Ahmad. Treating fungus-induced allergic asthma: Do VDACs have the answer! J Physiol. 598 (10), 1799–1800, 2020.

Journal Cover: The editors of The Journal of Physiology chose Fig 5C from this paper as the cover image for volume 598 (10), 2020.

Graeff R, Guedes A, Quintana R, Wendt-Hornickle E, Baldo C, Walseth T, O'Grady S, Kannan M. Novel Pathway of Adenosine Generation in the Lungs from NAD(+): Relevance to Allergic Airway Disease. Molecules, 25 (21), 1-18, 2020.

Refereed Articles on PubMed

O’Grady, SM, Ion Transport: Potassium Channels, Encyclopedia of Respiratory Medicine, 2nd Edition, Volume 1, pp 669-677, 2021.

O’Grady, S.M. (Invited review) Ion Transport, Potassium Channels. Encyclopedia of Respiratory Medicine In Press. 2020.

O’Grady, S.M. 2017. CFTR involvement in cell migration and epithelial restitution. In: Progress in Understanding Cystic Fibrosis. D.D. Sriramulu, Ed., Rijeka: InTech; 2017, pp 1-22.

Bankers-Fulbright, J. and S.M. O'Grady. 2012. Mechanisms of eosinophil degranulation: pH Regulation and release of major basic protein. In: Eosinophils: Structure, Biological Properties and Role in Disease. NOVA Science Publishers, Hauppauge, NY.

Brown, D.R. and S.M. O'Grady. 2008. The Ussing chamber and measurement of drug actions on mucosal ion transport. In: Current Protocols in Pharmacology. John Wiley, NY, 41:7.12.1-7.12.17, 2008.

Srisomboon, Y, K. Iijima, M. Colwell, P. Maniak, C. Faulk, H. Kita, and S. O'Grady, Allergen-stimulated secretion of DNA fragments by the airway epithelium enhances type 2 immune responses, Physiology, 38 (S1) 5730041, May 2023. https://doi.org/10.1152/physiol.2023.38.S1.5730041 (IF = 8.4)

Collins, M., M. Imbrogno, E. Kramer, J. Brewington, N. Zhang, P. Sharon, E. Kopras, J Meeker, H. Morgan, A. Ostmann, S. O'Grady, B. Trapnell, J. Clancy, K. Hudock, Neutrophil extracellular traps disrupt bronchial epithelial barrier function: Alpha-1 antitrypsin to the rescue. J. Cystic Fibrosis, 21: S223, 2022

Iijima, K., T. Kobayashi, K. Ohara, K. Matsumoto, R. Tei, S. O'Grady, H. Kita, Allergen-induced extracellular release of self-DNA promotes innate type 2 immune responses in the lung, J. Allergy Clin Immunol., 149: AB75, 2022

Almutlaq, R., A. Dayton, J. Ross, Y. Srisomboon, S. O'Grady, L.C. Evans, Exposure to excess albumin causes inflammatory activation of the proximal tubule, Hypertension, 79: AP082, 2022.

Moore, P., Wiggen, T., Kent, L., Arif, S., Lucas, S., O’Grady, S.M. Hunter, R., Anaerobic microbiota facilitate Pseudomonas aeruginosa access to the airway epithelium in a novel co-culture model of colonization. Journal of Cystic Fibrosis, 20, S195, 2021.

Ohara, K., Iijima, K., O'Grady, S.M., Kita, H., Detergent induces active release of IL-33 from airway epithelial cells and promotes innate type 2 responses in the lungs. Journal of Allergy and Clinical Immunology 147 (2), AB38, 2021.

Srisomboon, Y,  Maniak PJ,  Kita H, O'Grady SM. K2P channel inhibition enhances allergen‐induced ATP release by a mechanism involving PKC activation in human bronchial epithelial cells. FASEB J. 34(S1): doi.org/10.1096/fasebj.2020.34.s1.05204.

Srisomboon Y, Maniak PJ, Squillace D, Kita H, O’Grady SM. Simvastatin Inhibits Allergen-induced IL-33 Secretion in Human Bronchial Epithelial Cells by Blocking ATP Release and Ca2+ Uptake. FASEB J 33: 734.5-734.5, 2019.

O' Grady, S.M. Invited Seminar: City-wide Pulmonary Research Conference, Minneapolis MN, 06/25/2021. "Vital DNA Release by the Airway Epithelium and its role in Inflammation."

O' Grady, S.M. Invited Speaker (Zoom Presentation): Department of Biology, Virginia Commonwealth University, Richmond VA, 10/07/2020: “VDAC-1 mediated ATP release and type 2 immunity in airways”.

O' Grady, S.M. 2019. Epithelial ETosis and airway host-defense following fungal aeroallergen exposure. CVM Research Seminar, St. Paul, MN. March 6. 

O' Grady, S.M. 2018. Glucocorticoid regulation of airway epithelial ion transport during mucociliary differentiation. Department of Medicine, Minneapolis, MN. November 14.

Ingbar, D.H., M. Bhargara, and S.M. O'Grady. 2009. Mechanisms of alveolar epithelial chloride absorption. Am. J. Physiology [Lung Cell and Mol. Physiol.] 297: L813-L815.

Chanson, M., B.A. Kotsias, C. Peracchia, and S.M. O'Grady. 2007. Interaction of gap junction channels with other membrane channels and transporters. Prog. Biophys. Mol. Biol. 94:233-244.

O'Grady, S.M. 2006. Ion transport: Potassium channels. Encyclopedia of Respiratory Medicine 8:477-482.

Palmer, M.L., A.C. Fahrenkrug, and S.M. O'Grady. 2006. RNA interference and ion channel physiology. Cell Biochem. Biophys. 46:1-17.

O'Grady, S.M. and S.Y. Lee. 2005. Molecular diversity and function of voltage-gated (Kv) potassium channels in epithelial cells. Int. J. Biochem. Cell Biol. 37:1578-1594.

Lee, S.Y. and S.M. O'Grady. 2003. Modulation of ion channel function by P2Y receptors. Cell Biochem. Biophys. 39:75-88.

O'Grady, S.M. and S.Y. Lee. 2003. Chloride and potassium channels in alveolar epithelial cells. Am. J. Physiology (Lung Cell and Molecular Physiol.) 284:L689-L700.

O'Grady, S.M., X. Jiang, and D.H. Ingbar. 2000. CL channel activation is necessary for stimulation of amiloride-sensitive NA transport in cultured adult rat alveolar epithelial cells. Am. J. Physiol. [Lung Cell and Molecular Physiology] 278:L239-L244.

Bankers-Fulbright, J.L., G. Gleich, and S.M. O'Grady. 2001. Topical anesthetics useful for the treatment of cancer, U.S. patent #: 687, 389, 10/13/2001. Status: Allowed.

Bankers-Fulbright, J.L., G. Gleich, and S.M. O'Grady. 2001. Treatment of Eosinophil associated pathologies by modulating PKC-delta activity, U.S. Patent #: 687, 291, 10/13/2001. Status: Allowed.